Four pillars of heart failure: contemporary ... - Open Heart
WEBThe past two decades have heralded dramatic improvements in outcomes for people living with heart failure with reduced ejection fraction (HFrEF).1 The more widespread implementation of disease modifying pharmacological therapies,2 supported by landmark trials of renin-angiotensin system inhibitors3 and beta-blockers4 have improved longevity despite a background of an ageing and increasingly ...
Prospective arrhythmia surveillance after a COVID-19 diagnosis
WEBResults A total of 51 individuals (mean age 42±11 years, 65% women) underwent monitoring at a median 75 (IQR 34–126) days after a positive COVID-19 test. Median monitoring duration was 13.2 (IQR 10.5–13.8) days. No participant demonstrated atrial fibrillation, atrial flutter, sustained supraventricular tachycardia (SVT), sustained ...
Vitamin K2—a neglected player in cardiovascular health: a …
WEBVitamin K2 serves an important role in cardiovascular health through regulation of calcium homeostasis. Its effects on the cardiovascular system are mediated through activation of the anti-calcific protein known as matrix Gla protein. In its inactive form, this protein is associated with various markers of cardiovascular disease including increased arterial stiffness, vascular and valvular ...
Acute myocarditis caused by COVID-19 disease and following …
WEBCOVID-19: from subclinical myocardial injury to fulminant lethal myocarditis. SARS-CoV-2 gains entry into human cells by binding its cleaved spike protein (S1/S2 and S2ʹ sites) to the ACE2 membrane protein,1 which, can be found on ciliated columnar epithelial cells of the respiratory tract, type II pneumocytes and also cardiomyocytes.2 Since, failed human hearts have a higher percentage of ...
Myo-inositol for insulin resistance, metabolic syndrome, polycystic ...
WEBMyo-inositol, also known as inositol (cyclohexanehexol), is a cyclic carbohydrate with six hydroxyl groups.1 For a long time, it was considered a B vitamin (vitamin B8). However, it is not considered an essential nutrient because it is formed from glucose. Each kidney makes around 2 g of myo-inositol per day, and the average dietary intake is 0.5–1.0 g/day.2 3 The liver and brain also ...
Transcatheter mitral valve repair: an overview of current and future ...
WEBThe field of transcatheter mitral valve repair (TMVr) for mitral regurgitation (MR) is rapidly evolving. Besides the well-established transcatheter mitral edge-to-edge repair approach, there is also growing evidence for therapeutic strategies targeting the mitral annulus and mitral valve chordae. A patient-tailored approach, careful patient selection and an experienced interventional team is ...
Transcatheter tricuspid valve intervention techniques and …
WEBSevere tricuspid regurgitation (TR) is an undertreated common pathology associated with significant morbidity and mortality. Classically, surgical repair or valve replacement were the only therapeutic options and are associated with up to 10% postprocedural mortality. Transcatheter tricuspid valve interventions are a novel and effective therapeutic option for the treatment of significant TR ...
Harnessing the power of clinical decision support systems: …
WEBClinical decision support systems (CDSSs) are increasingly integrated into healthcare settings to improve patient outcomes, reduce medical errors and enhance clinical efficiency by providing clinicians with evidence-based recommendations at the point of care. However, the adoption and optimisation of these systems remain a challenge. This review aims to provide an overview of the current state ...
Defining metabolic acidosis - Open Heart
WEBMetabolic acidosis is a chronic condition that many people in the Western world have but do not realise it.1–3 It occurs when there is retention of acid in the body, which leads to a depletion in the bicarbonate stores of the body. The term metabolic acidosis is typically used when referring to low blood pH or acidemia due to a metabolic abnormality. However, this is inappropriate as most ...
The health benefits of vitamin K - Open Heart
WEBIntroduction. Vitamin K is a fat-soluble vitamin, important for the function of numerous proteins within the body, such as the coagulation factors (II, VII, IX, X and protein C and protein S), osteocalcin (a bone-forming protein) and matrix-Gla protein (MGP) (an anticalcification protein), to name a few.1–3 Vitamin K exists naturally as vitamin K 1 (phylloquinone) and vitamin K 2 ...